Frohlich Lab
  • Home
  • Research
    • Open Studies
    • Publications
  • Team
    • Alumni
    • Collaborators
  • Media
    • Gallery
  • tacs academy
    • tACS
    • FAQ
    • Participate
    • tACS Studies
    • Publications
    • About tACS academy
  • BOOK
  • Careers
  • Contact

Publications

A Discussion of tACS Literature

Transcranial alternating current stimulation entrains single-neuron activity in the primate brain.

10/15/2021

0 Comments

 
Krause, M. R., Vieira, P. G., Csorba, B. A., Pilly, P. K. & Pack, C. C. Transcranial alternating current stimulation entrains single-neuron activity in the primate brain. Proceedings of the National Academy of Sciences 116, 5747-5755, doi:10.1073/pnas.1815958116 (2019).
 
Summary:
  • Krause et al. applied tACS (4mA peak to peak) in two macaque monkeys and measured the effect on single-unit neural entrainment in the hippocampus and basal ganglia (HC/BG) via depth electrodes. tACS consistently influences the timing, but not the rate, of spiking activity. Delivered 2-mA tACS (4 mA peak-to-peak) through 2 scalp electrodes and measured average electric field strengths in the hippocampus and basal ganglia of 0.28 V/m in one monkey and 0.35 V/m in another monkey.
 
Pros:
  • Built Individualized head models from high-resolution MRI and intraoperative records of implant locations
  • Frequency (1-100Hz, ±1Hz bin) and location-specific tACS effect (increase PLV in HC/BG but not in TEO)
  • Sham condition (ramp up and down) controls for nonspecific sensory effects of stimulation
  • Another control where they mirrored the tACS montage and found reduced neural entrainment. – entrainment is unlikely to be caused by peripheral or retinal stimulation
Open question:
  • 2-mA tACS in a monkey will generate fields that are on average 3 times stronger than 2-mA tACS in humans. Would a weaker electric field have similar effect? – Their follow-up article: the entrainment persisted at weaker amplitudes at 1mA and 0.5mA.
  • Is this effect possibly be induced by neuronal entrainment in cortex, and indirectly entrain deep structures (hippocampus)?
 
Contributed by: Wei Huang
0 Comments



Leave a Reply.

    Authors

    Every week, there are new and exciting scientific papers published on studies that investigated tACS. Reading and understanding these papers unfortunately requires both access to (sometimes quite expensive) scientific journals and in-depth "insider knowledge." Our goal is to share with you brief summaries of tACS studies that give you a big-picture idea of what the publications are about. There are too many studies to feature all of them but we will continuously update this page. If you have a specific study you would like to get featured, please contact us. The contributors are personnel from the Frohlich Lab and the Carolina Center for Neurostimulation.

    Archives

    October 2021

    Categories

    All

    RSS Feed

Proudly powered by Weebly
  • Home
  • Research
    • Open Studies
    • Publications
  • Team
    • Alumni
    • Collaborators
  • Media
    • Gallery
  • tacs academy
    • tACS
    • FAQ
    • Participate
    • tACS Studies
    • Publications
    • About tACS academy
  • BOOK
  • Careers
  • Contact