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Open Studies Enrolling Participants

Together with the Carolina Center for Neurostimulation, we are actively recruiting participants for several clinical trials.
​
​Why participate? We find that people decide to participate in clinical trials since they are looking for a new and different approach to managing their mental health. Also, people often participate since they are motivated to help with the discovery and development of new treatments for their condition. if you have general questions about our clinical trials, we welcome you to contact us. We look forward to hearing from you! 

Studies Looking for Participants with Depression

Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression (CLACS): Single-Site Open-Label Pilot Study

We investigate the effects of 5 days of personalized non-invasive brain stimulation on mood in people with depressive symptoms in a clinical research trial.

Who is eligible:
     Ages 18-70
     Diagnosis of major depressive disorder
     Current depressive symptoms

What will you receive:
     Up to $300
​     Free parking at study site

Study Outline:
     1. Screening session (1h): Consent, eligibility, questionnaires. (remote option)
     2. Stimulation week (each day 1.5h): five consecutive days with 40 min non-invasive brain stimulation, questionnaires
     3. One-week follow-up (30 min): Online questionnaires.
     4. Two-week follow-up (1h): Questionnaires & assessments. (Remote option)

Take our online screening to find out if you are eligible: https://redcap.link/CLACSStudy 

Location: 
100 Market Street
Chapel Hill, NC 27516
CCN@med.unc.edu
IRB #22-3094

Augmenting Behavioral Activation (ABA) Study

This study provides a brief single-session of psychotherapy aimed at providing tools to manage depression. You may or may not receive non-invasive brain stimulation while receiving this therapy.

Who is Eligible:
    Ages 18 and older
     Current diagnosis of major depressive disorder
What will you receive:
    Opportunity to explore your values and receive new strategies for managing your depression
     Up to $100
     Free parking on site


You will be asked to complete a baseline session (3 hours), a treatment session (2 hours), a follow-up session (2.5 hours), and fill out questionnaires online (0.5 hours)

​Contact Erin (ABA_study@med.unc.edu) for more information or to schedule your phone screening.

 

Open Studies for Healthy Controls


 

The Effects of Transcranial Alternating Current Stimulation (tACS) on Memory Recall and Sleep-EEG in Healthy Elderly Participants

Study Purpose:
The purpose of this pilot study is to establish whether it is feasible to use a combination of gamma frequency tACS stimulation and at-home sleep EEG recordings to measure the offline effects of tACS on memory recall. Specifically, we are interested in determining if this protocol is acceptable among the population aged 50 and above. We aim to prepare for a large RCT in an elderly clinical population in the future.

Target Population:
  • Healthy elderly people, ages 50 and up.

Time Commitment:
  • Up to 7 hours spread across five study visits. Visits must be completed within the span of two weeks.

Compensation:
  • Up to $100.

Participants may qualify if:
  • You are willing to abstain from alcohol for 24 hours before each session
  •  You do NOT have a cardiac pacemaker
  • You are NOT diagnosed with a neurological, psychiatric, or sleep disorder
  • You have NOT recently engaged in shift work within the last three months, or have not regularly gone to bed past 3 AM during the last three months 
  • You do NOT have a severe chronic health condition affecting your lungs, liver, kidney, heart or brain
Interested?
​Take our online screening survey to find out if you are eligible: https://redcap.link/CHARGE
Or contact our study at CHARGE@med.unc.edu

Infection and Inflammation in Mild Cognitive Impairment

Study Purpose:
​The purpose of this study is to understand if activation of the immune system is different in patients with mild cognitive impairment when compared to people without mild cognitive impairment.

Target Population:
Participants between the ages of 50 and 80.

Time Commitment:
45-60 minutes.

Compensation:
Up to $30

Participants may qualify if they:
          • Are between 50 and 80 years
          • Do NOT have a current diagnosis and/or are receiving treatment for a neurological or psychiatric disorder
          • Do NOT have a blood disorder or history of adverse reactions to blood draws
          • Do NOT currently take antibiotics

Interested?
Please send us an email
 at cognition@med.unc.edu.

Study Coordinator:
Flavio Frohlich, PhD



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