Schwippel T, Pupillo F, Feldman Z, Walker C, Townsend L, Rubinow D, Frohlich F. Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder: An Open-Label Pilot Study. Am J Psychiatry. 2024 Aug 7:appiajp20230838. doi: 10.1176/appi.ajp.20230838. Epub ahead of print. PMID: 39108159. [pdf]
Guirguis V, Pupillo F, Rodrigues S, Walker N, Roth H, Liedig CE, Maggi RG, Breitschwerdt EB, Frohlich F. Bartonella spp. infection in people with Mild Cognitive Impairment: A pilot study. PLoS One. 2024 Aug 22;19(8):e0307060. doi: 10.1371/journal.pone.0307060. PMID: 39172940; PMCID: PMC11340988. [pdf]
Mark JI, Riddle J, Gangwani R, Huang B, Fröhlich F, Cassidy JM. Cross-Frequency Coupling as a Biomarker for Early Stroke Recovery. Neurorehabil Neural Repair. 2024 Jul;38(7):506-517. doi: 10.1177/15459683241257523. Epub 2024 Jun 6. PMID: 38842027; PMCID: PMC11179969. [pdf]
Ross G, Radtke-Schuller S, Frohlich F. Ferret as a model system for studying the anatomy and function of the prefrontal cortex: A systematic review. Neurosci Biobehav Rev. 2024 May 6;162:105701. doi: 10.1016/j.neubiorev.2024.105701. Epub ahead of print. PMID: 38718987. [pdf]
Riddle J, McPherson T, Sheikh A, Shin H, Hadar E, Frohlich F. Internal Representations Are Prioritized by Frontoparietal Theta Connectivity and Suppressed by alpha Oscillation Dynamics: Evidence from Concurrent Transcranial Magnetic Stimulation EEG and Invasive EEG. J Neurosci. 2024 Apr 10;44(15):e1381232024. doi: 10.1523/JNEUROSCI.1381-23.2024. PMID: 38395616; PMCID: PMC11007311.
Huang, W. A., Zhou, Z. C., Stitt, I. M., Ramasamy, N. S., Radtke-Schuller, S., & Frohlich, F. (2024). Causal oscillations in the visual thalamo-cortical network in sustained attention in ferrets. Current biology : CB, S0960-9822(23)01767-0. Advance online publication. https://doi.org/10.1016/j.cub.2023.12.067 [pdf]
2023
Stewart, Z., Korsapathy, S., & Frohlich, F. (2023). Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms. Frontiers in Psychiatry, 14, 1244121. https://doi.org/10.3389/fpsyt.2023.1244121 [pdf]
Fang, Q., & Frohlich, F. (2023). Dissection of neuronal circuits underlying sustained attention with the five-choice serial reaction time task. Neuroscience and biobehavioral reviews, 152, 105306. Advance online publication. https://doi.org/10.1016/j.neubiorev.2023.105306 [pdf]
Potok, W., van der Groen, O., Sivachelvam, S., Baechinger, M., Fröhlich, F., Kish, L. B., & Wenderoth, N. (2023). Contrast detection is enhanced by deterministic, high-frequency transcranial alternating current stimulation with triangle and sine waveform. Journal of neurophysiology, 10.1152/jn.00465.2022. Advance online publication. https://doi.org/10.1152/jn.00465.2022. [pdf]
Sidelinger, L., Zhang, M., Frohlich, F., & Daughters, S. B. (2023). Day-to-day individual alpha frequency variability measured by a mobile EEG device relates to anxiety. The European journal of neuroscience, 10.1111/ejn.16002. Advance online publication. https://doi.org/10.1111/ejn.16002 [pdf]
2022
Zhang, M., Force, R. B., Walker, C., Ahn, S., Jarskog, L. F., & Frohlich, F. (2022). Alpha transcranial alternating current stimulation reduces depressive symptoms in people with schizophrenia and auditory hallucinations: a double-blind, randomized pilot clinical trial. Schizophrenia (Heidelberg, Germany), 8(1), 114. https://doi.org/10.1038/s41537-022-00321-0 [pdf] Fröhlich, F., & Jarskog, L. F. (2022). Non-Invasive Brain Stimulation in Schizophrenia. In E. M. Wassermann, A. V. Peterchev, U. Ziemann, S. H. Lisanby, H. R. Siebner, & V. Walsh (Eds.), The Oxford Handbook of Transcranial Stimulation, Second Edition (2nd ed., p. C43.P1-C43.S16). Oxford University Press. https://doi.org/10.1093/oxfordhb/9780198832256.013.43 [pdf]
Riddle, J., & Frohlich, F. (2022). Mental Activity as the Bridge between Neural Biomarkers and Symptoms of Psychiatric Illness. Clinical EEG and neuroscience, 15500594221112417. Advance online publication. https://doi.org/10.1177/15500594221112417 [pdf]
Riddle, J., Rubinow, D. R., & Frohlich, F. (2022). Effect of tACS on prefrontal neural activity is menstrual phase dependent in patients with premenstrual dysphoric disorder. Brain stimulation, S1935-861X(22)00167-X. Advance online publication. https://doi.org/10.1016/j.brs.2022.07.052 [pdf]
Zhang, M., Riddle, J., & Frohlich, F. (2022). Closed-loop control of bistable symptom states. Brain stimulation, 15(2), 454–456. https://doi.org/10.1016/j.brs.2022.02.010 [pdf]
Zhang, M., & Frohlich, F. (2022). Cell type-specific excitability probed by optogenetic stimulation depends on the phase of the alpha oscillation. Brain stimulation, 15(2), 472–482. https://doi.org/10.1016/j.brs.2022.02.014 [pdf]
Sklerov, M., Browner, N., Dayan, E., Rubinow, D., & Frohlich, F. (2022). Autonomic and Depression Symptoms in Parkinson's Disease: Clinical Evidence for Overlapping Physiology. Journal of Parkinson's disease, 10.3233/JPD-213075. Advance online publication. https://doi.org/10.3233/JPD-213075. [pdf]
2021
Riddle J, Alexander ML, Schiller CE, Rubinow DR, Frohlich F. Reward-Based Decision-Making Engages Distinct Modes of Cross-Frequency Coupling. Cereb Cortex. 2021 Oct 8:bhab336. doi: 10.1093/cercor/bhab336. Epub ahead of print. PMID: 34622271. [pdf]
McFerren A, Riddle J, Walker C, Buse JB, Frohlich F. Causal role of frontal-midline theta in cognitive effort: a pilot study. J Neurophysiol. 2021 Oct 1;126(4):1221-1233. doi: 10.1152/jn.00068.2021. Epub 2021 Sep 1. PMID: 34469696. [pdf]
Frohlich F, Riddle J, Ugen G, Lersch F. Brainwave entrainment for the treatment of chronic pain: comment onBr J Pain 2020; 14: 161-70. Br J Pain. 2021 Aug;15(3):369-370. doi: 10.1177/2049463721994614. Epub 2021 Mar 2. PMID: 34381615; PMCID: PMC8339944. [pdf]
Riddle J, Alexander ML, Schiller CE, Rubinow DR, Frohlich F. Reduction in Left Frontal Alpha Oscillations by Transcranial Alternating Current Stimulation in Major Depressive Disorder Is Context Dependent in a Randomized Clinical Trial. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Jul 14:S2451-9022(21)00194-4. doi: 10.1016/j.bpsc.2021.07.001. Epub ahead of print. PMID: 34273556. [pdf]
Frohlich F, Riddle J, Abramowitz JS. Transcranial alternating current stimulation for the treatment of obsessive-compulsive disorder? Brain Stimul. 2021 Jul-Aug;14(4):1048-1050. doi: 10.1016/j.brs.2021.06.014. Epub 2021 Jun 27. PMID: 34192553. [pdf]
Frohlich F, Ahn S. Differing dose details and controlling confounding covariates in modulating motor cortex excitability by transcranial direct current stimulation. Brain Stimul. 2021 Jul-Aug;14(4):947-948. doi: 10.1016/j.brs.2021.05.015. Epub 2021 Jun 10. PMID: 34118495. [pdf]
Riddle J, McFerren A, Frohlich F.Causal role of cross-frequency coupling in distinct components of cognitive control. Prog Neurobiol. 2021 Jul;202:102033. doi: 10.1016/j.pneurobio.2021.102033. Epub 2021 Mar 16. PMID: 33741402; PMCID: PMC8184612. [pdf]
Huang WA, Stitt IM, Negahbani E, Passey DJ, Ahn S, Davey M, Dannhauer M, Doan TT, Hoover AC, Peterchev AV, Radtke-Schuller S, Fröhlich F. Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform. Nat Commun. 2021 May 25;12(1):3151. doi: 10.1038/s41467-021-23021-2. PMID: 34035240; PMCID: PMC8149416. [pdf]
West EA, Niedringhaus M, Ortega HK, Haake RM, Frohlich F, Carelli RM. Noninvasive Brain Stimulation Rescues Cocaine-Induced Prefrontal Hypoactivity and Restores Flexible Behavior. Biol Psychiatry. 2021 May 15;89(10):1001-1011. doi: 10.1016/j.biopsych.2020.12.027. Epub 2021 Jan 8. PMID: 33678418; PMCID: PMC8106639. [pdf]
Riddle J, Frohlich F. Targeting neural oscillations with transcranial alternating current stimulation. Brain Res. 2021 Apr 20;1765:147491. doi: 10.1016/j.brainres.2021.147491. Epub ahead of print. PMID: 33887251. [pdf]
Frohlich F, Riddle J. Conducting double-blind placebo-controlled clinical trials of transcranial alternating current stimulation (tACS). Transl Psychiatry. 2021 May 12;11(1):284. doi: 10.1038/s41398-021-01391-x. PMID: 33980854; PMCID: PMC8116328. [pdf]
Riddle J, Rubinow DR, Girdler S, Frohlich F.Disinhibition of right inferior frontal gyrus underlies alpha asymmetry in women with low testosterone. Biol Psychol. 2021 Apr;161:108061. doi: 10.1016/j.biopsycho.2021.108061. Epub 2021 Mar 8. PMID: 33705806; PMCID: PMC8113111. [pdf]
Lashnits E, Maggi R, Jarskog F, Bradley J, Breitschwerdt E, Frohlich F. Schizophrenia and Bartonella spp. Infection: A Pilot Case-Control Study. Vector Borne Zoonotic Dis. 2021 Jun;21(6):413-421. doi: 10.1089/vbz.2020.2729. Epub 2021 Mar 15. PMID: 33728987; PMCID: PMC8170724. [pdf]
Frohlich F, Riddle J. Transcranial alternating current stimulation (tACS) as a treatment for fibromyalgia syndrome? Eur Arch Psychiatry Clin Neurosci. 2021 Mar 13. doi: 10.1007/s00406-021-01253-z. Epub ahead of print. PMID: 33715022. [pdf]
Ahn S, Fröhlich F. Pinging the brain with transcranial magnetic stimulation reveals cortical reactivity in time and space. Brain Stimul. 2021 Mar-Apr;14(2):304-315. doi: 10.1016/j.brs.2021.01.018. Epub 2021 Jan 28. PMID: 33516859; PMCID: PMC7987756. [pdf]
Ahn S, Gleghorn D, Doudican B, Fröhlich F, Cha YH. Transcranial Alternating Current Stimulation Reduces Network Hypersynchrony and Persistent Vertigo. Neuromodulation. 2021 Mar 23. doi: 10.1111/ner.13389. Epub ahead of print. PMID: 33757158. [pdf]
Walker CP, Buse JB, Frohlich F. Experimental increase of blood glucose alters resting state EEG measures of excitation-inhibition balance. Exp Physiol. 2021 Apr;106(4):803-811. doi: 10.1113/EP089211. Epub 2021 Feb 27. PMID: 33507550. [pdf]
Force RB, Riddle J, Jarskog LF, Fröhlich F. A case study of the feasibility of weekly tACS for the treatment of auditory hallucinations in schizophrenia. Brain Stimul. 2021 Mar-Apr;14(2):361-363. doi: 10.1016/j.brs.2021.01.014. Epub 2021 Jan 27. PMID: 33515747. [pdf]
McKim TH, Dove SJ, Robinson DL, Fröhlich F, Boettiger CA. Addiction history moderates the effect of prefrontal 10-Hz transcranial alternating current stimulation on habitual action selection. J Neurophysiol. 2021 Mar 1;125(3):768-780. doi: 10.1152/jn.00180.2020. Epub 2020 Dec 23. PMID: 33356905; PMCID: PMC7988748. [pdf]
Walker CP, McFerren AL, Rammani DR, Buse JB, Frohlich F. Metabolic state and gustatory perception shapes dynamic interplay between cortical excitability and motor response. Brain Stimul. 2021 Jan-Feb;14(1):202-205. doi: 10.1016/j.brs.2020.12.002. Epub 2020 Dec 11. PMID: 33309841. [pdf]
Lersch F, Hight D, Frohlich F. Entrainment of brain network oscillations in anaesthesia. Comment on Br J Anaesth 2020; 125: 330-335. Br J Anaesth. 2021 Jan;126(1):e11-e12. doi: 10.1016/j.bja.2020.08.028. Epub 2020 Sep 8. PMID: 32917374. [pdf]
Frohlich, F., Townsend, L. Closed-Loop Transcranial Alternating Current Stimulation: Towards Personalized Non-invasive Brain Stimulation for the Treatment of Psychiatric Illnesses. Curr Behav Neurosci Rep8, 51–57 (2021). https://doi.org/10.1007/s40473-021-00227-8 [pdf]
2020
Zhou ZC, Huang WA, Yu Y, Negahbani E, Stitt IM, Alexander ML, Hamm JP, Kato HK, Fröhlich F. Stimulus-specific regulation of visual oddball differentiation in posterior parietal cortex Sci Rep 2020 Aug doi: 10.1038/s41598-020-70448-6 [pdf]
Daughters SB, Yi JY, Phillips RD, Carelli RM, Fröhlich F. Alpha-tACS effect on inhibitory control and feasibility of administration in community outpatient substance use treatment Drug Alcohol Depend 2020 Jun doi: 10.1016/j.drugalcdep.2020.108132 [pdf]
Riddle J, Ahn S, McPherson T, Girdler S, Frohlich F. Progesterone modulates theta oscillations in the frontal-parietal network SPR Psyp 2020 May 24. doi: 10.1111/psyp.13632 [pdf]
Riddle J, McPherson T, Atkins AK, Walker C, Ahn S, Frohlich F.Brain-derived neurotrophic factor (BDNF) polymorphism may influence the efficacy of tACS to modulate neural oscillations Brain Stimul. 2020 Apr 21. pii: S1935-861X(20)30091-7. doi: 10.1016/j.brs.2020.04.012. [pdf]
Mattoni M, Ahn S, Fröhlich C, Fröhlich F. Exploring the relationship between geomagnetic activity and human heart rate variabilityEur J Appl Physiol. 2020 Apr 18. doi: 10.1007/s00421-020-04369-7. [pdf]
Dugyala S, Ptacek T, Simon J, Li Y, Frohlich F.Putative modulation of the gut microbiome by probiotics enhances preference for novelty in a preliminary double-blind placebo-controlled study in ferrets Animal Microbiome (2020) 2:14 doi.org/10.1186/s42523-020-00030-y [pdf]
2019
Riddle J, Rubinow DR, Frohlich F.A case study of weekly tACS for the treatment of major depressive disorderBrain Stimul. 2019 Dec 17;13(3):576-577. doi: 10.1016/j.brs.2019.12.016. [pdf]
Prim JH, Ahn S, Davila MI, Alexander ML, McCulloch KL, Fröhlich F. Targeting the Autonomic Nervous System Balance in Patients with Chronic Low Back Pain Using Transcranial Alternating Current Stimulation: A Randomized, Crossover, Double-Blind, Placebo-Controlled Pilot Study J Pain Res. 2019 Dec 11;12:3265-3277. doi: 10.2147/JPR.S208030. eCollection 2019. [pdf]
Ahn S, Lustenberger C, Jarskog LF, Fröhlich F.Neurophysiological substrates of configural face perception in schizotypy Schizophr Res. 2019 Dec 2. pii: S0920-9964(19)30503-1. doi: 10.1016/j.schres.2019.11.005. [pdf]
Algapan S, Riddle J, Huang WJ, Hadar E, Shin HW, Fröhlich F. Network-Targeted, Multi-site Direct Cortical Stimulation Enhances Working Memory by Modulating Phase Lag of Low-Frequency Oscillations. Journal of Pain Research. 2019 Nov 26;29(9):2590-2598.e4. doi: 10.1016/j.celrep.2019.10.072. [pdf]
McPherson T, Berger D, Alagapan S, Fröhlich F. Active and Passive Rhythmic Music Therapy Interventions Differentially Modulate Sympathetic Autonomic Nervous System Activity. Journal of Music Therapy. 2019 Jun 1-25. doi: doi:10.1093/jmt/thz007 [pdf]
Alexander ML, Alagapan S, Lugo CE, Mellin JM, Lustenberger C, Rubinow D, Fröhlich F. Double-blind, randomized pilot clinical trial targeting alpha oscillations with transcranial alternating current stimulation (TACS) for the treatment of major depressive disorder (MDD). Translational Psychiatry. 2019 Mar 5;9:106. https://doi.org/10.1038/s41398-019-0439-0. [pdf]
Ahn S, Mellin JM, Alagapan S, Alexander ML, Gilmore J, Jarskog F, Fröhlich F. Targeting reduced neural oscillations in patients with schizophrenia by transcranial alternating current stimulation. Neuroimage. 2019 Feb 1;186:126-136. doi: 10.1016/j.neuroimage.2018.10.056. [pdf] Alagapan S, Lustenberger C, Hadar E, Shin H W, Fröhlich F. Low-frequency direct cortical stimulation of left superior frontal gyrus enhances working memory performance. NeuroImage. 2019 Jan 1;184:697-706. doi: 10.1016/j.neuroimage.2018.09.064. [pdf]
2018
Mustafa Sahin, Stephanie R. Jones, John A. Sweeney, Elizabeth Berry-Kravis, Barry W. Connors, Joshua B. Ewen, Adam L. Hartman, April R. Levin, William Z. Potter, Laura A. Mamounas, on behalf of the Biomarker Workshop Faculty. Discovering translational biomarkers in neurodevelopmental disorders. Nat Rev Drug Dis. 2018 Dec 20;1-2. doi:10.1038/d41573-018- 000F10-7 [pdf]
Li G, Henriques C, Fröhlich F. Rhythmic modulation of thalamic oscillations depends on intrinsic cellular dynamics. Journal of Neural Engineering. 2018 Dec 12;16(1):016013. doi: 10.1088/1741-2552/aaeb03. [pdf]
Alagapan S, Shin H, Fröhlich F, Wu H. Diffusion geometry approach to efficiently remove electrical stimulation artifacts in intracranial electroencephalography. Journal of Neural Engineering. 2018 Nov 21;1-32 doi: 10.1088/1741-2552/aaf2ba. [pdf]
Sheffield A, Sangtae A, Alagapan S, Fröhlich F.Modulating neural oscillations by transcranial static magnetic field stimulation of the dorsolateral prefrontal cortex: A crossover, double‐blind, sham‐controlled pilot study. European Journal of Neuroscience. 2018 Oct 31; 1-13. doi: 10.1111/ejn.14232. [pdf]
Negahbani E, Schmidt S, Mishal N, Fröhlich F. Neuromodulation-dependent effect of gated high-frequency, LFMS-like electric field stimulation in mouse cortical slices. European Journal of Neuroscience. 2018 Oct 30;1-10. doi: 10.1111/ejn.14273. [pdf]
Ahn S, Prim J, Alexander ML, McCulloch K, Fröhlich F. Identifying and engaging neuronal oscillations by transcranial alternating current stimulation in patients with chronic lower back pain: A randomized, crossover, double-blind, sham-controlled pilot study. The Journal of Pain. 2018 Sep 27;00:00:1-11. doi: 10.1016/j.jpain.2018.09.004 [pdf]
Li Y, Dugyala S, Ptacek T, Gilmore J, Fröhlich F. Maternal immune activation alters adult behavior, gut microbiome and juvenile brain oscillations in ferrets. eNuro. 2018 Sep. doi: 10.1523/ENEURO.0313-18.2018. [pdf]
Kurmann R, Gast H, Schindler K, Fröhlich F. Rational design of transcranial alternating current stimulation: Identification, engagement, and validation of network oscillations as treatment targets. Clinical and Translational Neuroscience. 2018 Aug 23;2:2:2514183X18793515. doi: 10.1177/2514183X18793515 [pdf]
Stitt I, Zhou ZC, Radtke-Schuller S, Fröhlich F.Arousal dependent modulation of thalamo-cortical functional interaction. Nat Commun. 2018 Jun 25;9(1):2455. doi: 10.1038/s41467-018-04785-6. Epub 2018 Jun 25 [pdf]
Lu J, Li C, Singh-Alvarado J, Zhou ZC, Fröhlich F, Mooney R, Wang F. MIN1PIPE: A miniscope 1-photon-based calcium imaging signal extraction pipeline. Cell Rep. 2018 Jun 19;23(12):3673-3684. doi: 10.1016/j.celrep.2018.05.062. [pdf]
Kasten FH, Negahbani E, Fröhlich F, Herrmann CS. Non-linear transfer characteristics of stimulation and recording hardware account for spurious low-frequency artifacts during amplitude modulated transcranial alternating current stimulation (AM-tACS). Neuroimage. 2018 Oct 1;179:134-143. doi: 10.1016/j.neuroimage.2018.05.068. Epub 2018 May 31. [pdf]
Yu C, Li Y, Stitt IM, Zhou ZC, Sellers KK, Fröhlich F. Theta Oscillations Organize Spiking Activity in Higher-Order Visual Thalamus during Sustained Attention. eNeuro. 2018 Apr 3;5(1). pii: ENEURO.0384-17.2018. doi: 10.1523/ENEURO.0384-17.2018. eCollection 2018 Jan-Feb. [pdf]
Mellin JM, Alagapan S, Lustenberger C, Lugo CE, Alexander ML, Gilmore JH, Jarskog LF, Fröhlich F. Randomized trial of transcranial alternating current stimulation for treatment of auditory hallucinations in schizophrenia. Eur Psychiatry. 2018 Jun;51:25-33. doi: 10.1016/j.eurpsy.2018.01.004. Epub 2018 Mar 11. [pdf]
Page J, Lustenberger C, Fröhlich F. Social, motor, and cognitive development through the lens of sleep network dynamics in infants and toddlers between 12 and 30 months of age. Sleep, 2018 Apr;41(4). doi: 10.1093/sleep/zsyo24. Epub 2018 Feb 2. [pdf]
Toloza EHS, Negahbani E, Fröhlich F.Ih interacts with somato-dendritic structure to determine frequency response to weak alternating electric field stimulation. J Neurophysiol. 2018 Mar 1;119(3):1029-1036. doi: 10.1152/jn.00541.2017. Epub 2017 Nov 29. [pdf]
Negahbani E, Kasten FH, Herrmann CS, and Fröhlich F. Targeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation. Neuroimage. 2018 Jun;173:3-12. doi: 10.1016/j.neuroimage.2018.02.005. Epub 2018 Feb 7. [pdf]
Bikson M, Brunoni AR, Charvet LE, Clark VP, Cohen LG, Deng ZD, Dmochowski J, Edwards DJ, Fröhlich F, Kappenman ES, Lim KO, Loo C, Mantovani A, McMullen DP, Parra LC, Pearson M, Richardson JD, Rumsey JM, Sehatpour P, Sommers D, Unal G, Wassermann EM, Woods AJ, Lisanby SH. Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop. Brain Stimul. 2018 May - Jun;11(3):465-480. doi: 10.1016/j.brs.2017.12.008. Epub 2017 Dec 29. Review. [pdf]
Lustenberger C, Patel YA, Alagapan S, Page JM, Price B, Boyle MR, Fröhlich F. High-density EEG characterization of brain responses to auditory rhythmic stimuli during wakefulness and NREM sleep.Neuroimage. 2018 Apr 1;169:57-68. doi: 10.1016/j.neuroimage.2017.12.007. Epub 2017 Dec 6 [pdf]
2017
Lefebvre J, Hutt A, and Fröhlich F. Stochastic resonance mediates the state-dependent effect of periodic stimulation on cortical alpha oscillations. Elife. 2017 Dec 27;6. pii: e32054. doi: 10.7554/eLife.32054. [pdf]
Li Y, Yu C, Zhou ZC, Stitt I, Sellers KK, Gilmore JH, Fröhlich F. Early Development of Network Oscillations in the Ferret Visual Cortex. Sci Rep. 2017 Dec 19;7(1):17766. doi: 10.1038/s41598-017-17502-y. [pdf]
Li G, Henriquez CS, Fröhlich F (2017) Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation. PLoS Comput Biol. 2017 Oct 26;13(10):e1005797. doi: 10.1371/journal.pcbi.1005797. eCollection 2017 Oct. [pdf]
Wollstadt P, Sellers KK, Rudelt L, Priesemann V, Hutt A, Fröhlich F, Wibral M. Breakdown of local information processing may underlie isoflurane anesthesia effects. PLoS Comput Biol. 2017 Jun 1;13(6):e1005511. doi: 10.1371/journal.pcbi.1005511. eCollection 2017 Jun. [pdf]
Thut G, Bergmann TO, Fröhlich F, Soekadar SR, Brittain JS, Valero-Cabré A, Sack AT, Miniussi C, Antal A, Siebner HR, Ziemann U, Herrmann CS. Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper. Clin Neurophysiol. 2017 May;128(5):843-857. doi: 10.1016/j.clinph.2017.01.003. Epub 2017 Jan 29. Review. [pdf]
Philip NS, Nelson BG, Fröhlich F, Lim KO, Widge AS, Carpenter LL. Low-Intensity Transcranial Current Stimulation in Psychiatry. Am J Psychiatry. 2017 Jul 1;174(7):628-639. doi: 10.1176/appi.ajp.2017.16090996. Epub 2017 Feb 24. Review. [pdf]
2016
Sellers KK, Yu C, Zhou ZC, Stitt I, Li Y, Radtke-Schuller S, Alagapan S,Fröhlich F. Oscillatory dynamics in the frontoparietal attention network during sustained attention in the ferret. Cell Rep. 2016 Sep 13;16(11):2864-2874. doi: 10.1016/j.celrep.2016.08.055. [pdf]
F. Fröhlich, S. Alagapan, M.R. Boyle, F. Hamilton, G. Li, C. Lustenberger, and S.L. Schmidt Target Engagement with Transcranial Current Stimulation. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management. 197-222. 10.1007/978-3-319-33967-2_11. Sep 2016 [pdf]
Zhou ZC, Salzwedel AP, Radtke-Schuller S, Li Y, Sellers KK, Gilmore JH, Shih YI, Fröhlich F, Gao W. Resting state network topology of the ferret brain. Neuroimage. 2016 Dec;143:70-81. doi: 10.1016/j.neuroimage.2016.09.003. Epub 2016 Sep 2. [pdf]
Schmidt SL, Dorsett CR, Iyengar AK, Fröhlich F. Interaction of Intrinsic and Synaptic Currents Mediate Network Resonance Driven by Layer V Pyramidal Cells. Cereb Cortex. 2017 Sep 1;27(9):4396-4410. doi: 10.1093/cercor/bhw242. [pdf]
Lustenberger C, Boyle MR, Alagapan S, Mellin JM, Vaughn BV, Fröhlich F. Feedback-Controlled Transcranial Alternating Current Stimulation Reveals a Functional Role of Sleep Spindles in Motor Memory Consolidation. Curr Biol. 2016 Aug 22;26(16):2127-36. doi: 10.1016/j.cub.2016.06.044. Epub 2016 Jul 28. [pdf]
Hopfinger JB, Parsons J, Fröhlich F. Differential effects of 10-Hz and 40-Hz transcranial alternating current stimulation (tACS) on endogenous versus exogenous attention. Cogn Neurosci. 2017 Apr;8(2):102-111. doi: 10.1080/17588928.2016.1194261. Epub 2016 Jun 14. [pdf]
beim Graben P, Sellers KK, Fröhlich F, Hutt A. Optimal estimation of recurrence structures from time series. Epl. 2016 May;114(3). doi:Artn 38003 10.1209/0295-5075/114/38003 [pdf]
Zhou ZC, Yu C, Sellers KK, Fröhlich F. Dorso-lateral frontal cortex of the ferret encodes perceptual difficulty during visual discrimination. Sci Rep. 2016 Mar 30;6:23568. doi: 10.1038/srep23568. [pdf]
Alagapan S, Schmidt SL, Lefebvre J, Hadar E, Shin HW, Fröhlich F. Modulation of cortical oscillations by low-frequency direct cortical stimulation is state-dependent. PLoS Biol. 2016 Mar 29;14(3):e1002424. doi: 10.1371/journal.pbio.1002424. eCollection 2016 Mar. [pdf]
Fröhlich F, Burrello TN, Mellin JM, Cordle AL, Lustenberger CM, Gilmore JH, Jarskog LF. Exploratory study of once-daily transcranial direct current stimulation (tDCS) as a treatment for auditory hallucinations in schizophrenia. Eur Psychiatry. 2016 Mar;33:54-60. doi: 10.1016/j.eurpsy.2015.11.005. Epub 2016 Feb 8. [pdf]
Tošić T, Sellers KK, Fröhlich F, Fedontenkova M, Beim Graben P, Hutt A. Statistical Frequency-Dependent Analysis of Trial-to-Trial Variability in Single Time Series by Recurrence Plots. Front Syst Neurosci. 2016 Jan 14;9:184. doi: 10.3389/fnsys.2015.00184. eCollection 2015. [pdf]
Yu C, Sellers KK, Radtke-Schuller S, Lu J, Xing L, Ghukasyan V, Li Y, Shih Yl, Murrow R, Fröhlich F. Structural and Functional Connectivity between the Lateral Posterior-Pulvinar Complex and Primary Visual Cortex in the Ferret. Eur J Neurosci. 2016 Jan;43(2):230-44. doi: 10.1111/ejn.13116. Epub 2016 Jan 4. [pdf]
2015
Fröhlich F, Sellers KK, Cordle AL. Targeting the neurophysiology of cognitive systems with transcranial alternating current stimulation. Expert Rev Neurother. 2015 Feb;15(2):145-67. doi: 10.1586/14737175.2015.992782. Epub 2014 Dec 30. Review. [pdf]
Sellers KK, Bennett DV, Fröhlich F. Frequency-band signatures of visual responses to naturalistic input in ferret primary visual cortex during free viewing.Brain Res. 2015 Feb 19;1598:31-45. doi: 10.1016/j.brainres.2014.12.016. Epub 2014 Dec 12. [pdf]
Fröhlich F. Experiments and models of cortical oscillations as a target for noninvasive brain stimulation. Prog Brain Res. 2015;222:41-73. doi: 10.1016/bs.pbr.2015.07.025. Epub 2015 Aug 28. Review. [pdf]
Wollstadt P, Sellers KK, Hutt A, Fröhlich F, Wibral M. Anesthesia-related changes in information transfer may be caused by reduction in local information generation. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:4045-8. doi: 10.1109/EMBC.2015.7319282. [pdf]
Fröhlich F. Tuning out the Blues – Thalamo-Cortical Rhythms as a Successful Target for Treating Depression. Brain Stimul. 2015 Nov-Dec;8(6):1007-9. doi: 10.1016/j.brs.2015.07.040. Epub 2015 Jul 31. [pdf]
Sellers KK, Mellin JM, Lustenberger CM, Boyle MR, Lee WH, Peterchev AV, Fröhlich F. Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test. Behav Brain Res. 2015 Sep 1;290:32-44. doi: 10.1016/j.bbr.2015.04.031. Epub 2015 Apr 28. [pdf]
Sellers KK, Bennett DV, Hutt A, Williams JH, Fröhlich F. Awake versus Anesthetized: Layer-Specific Sensory Processing in Visual Cortex and Functional Connectivity between Cortical Areas. J Neurophysiol. 2015 Jun 1;113(10):3798-815. doi: 10.1152/jn.00923.2014. Epub 2015 Apr 1. [pdf]
Lustenberger C, Boyle MR, Foulser AA, Mellin JM, Fröhlich F. Role of frontal alpha oscillations in creativity. Cortex. 2015 Jun;67:74-82. doi: 10.1016/j.cortex.2015.03.012. Epub 2015 Apr 1. [pdf]
Youngblood MW, Chen WC, Mishra AM, Enamandram S, Sanganahalli BG, Motelow JE, Bai HX, Fröhlich F, Gribizis A, Lighten A, Hyder F, Blumenfeld H. Rhythmic 3-4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures. Neuroimage. 2015 Apr 1;109:368-77. doi: 10.1016/j.neuroimage.2014.12.066. Epub 2015 Jan 3. [pdf]
2014
Schmidt SL, Iyengar AK, Foulser A, Boyle MR, Fröhlich F.Endogenous Cortical Oscillations Constrain Neuromodulation by Weak Electric Fields.Brain Stimul. 2014 Nov-Dec;7(6):878-89. doi: 10.1016/j.brs.2014.07.033. Epub 2014 Jul 19. [pdf] Fröhlich F.Endogenous and exogenous electric fields as modifiers of brain activity: rational design of noninvasive brain stimulation with transcranial alternating current stimulation. Dialogues Clin Neurosci. 2014 Mar;16(1):93-102. Review. [pdf]
Hammad M, Schmidt SL, Zhang X, Bray R, Fröhlich F, Ghashghaei HT. Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice. Cereb Cortex. 2015 Sep;25(9):2970-9. doi: 10.1093/cercor/bhu094. Epub 2014 May 8. [pdf]
2013
Sellers KK, Bennett DV, Hutt A, Fröhlich F. Anesthesia Differentially Modulates Spontaneous Network Dynamics by Cortical Area and Layer. J Neurophysiol. 2013 Dec;110(12):2739-51. doi: 10.1152/jn.00404.2013. Epub 2013 Sep 18. [pdf]
Fröhlich F, Schmidt SL. Rational design of transcranial current stimulation (TCS) through mechanistic insights into cortical network dynamics. Front Hum Neurosci. 2013 Nov 26;7:804. doi: 10.3389/fnhum.2013.00804. Review. [pdf]
Kutchko KM, Fröhlich F. Emergence of Metastable State Dynamics in Interconnected Cortical Networks with Propagation Delays. PLoS Comput Biol. 2013 Oct;9(10):e1003304. doi: 10.1371/journal.pcbi.1003304. Epub 2013 Oct 24. [pdf]
Ali MM, Sellers KK, Fröhlich F. Transcranial alternating current stimulation modulates large-scale cortical network activity by network resonance. J Neurosci. 2013 Jul 3;33(27):11262-75. doi: 10.1523/JNEUROSCI.5867-12.2013. [pdf]
Schmidt SL, Chew EY, Bennett DV, Hammad MA, Fröhlich F. Differential effects of cholinergic and noradrenergic neuromodulation on spontaneous cortical network dynamics. Neuropharmacology. 2013 Sep;72:259-73. doi: 10.1016/j.neuropharm.2013.04.045. Epub 2013 May 3. [pdf]
2010
F Fröhlich, TJ Sejnowski, M Bazhenov. Network bistability mediates spontaneous transitions between normal and pathological brain states. J Neurosci. 2010 Aug 11;30(32):10734-43. doi: 10.1523/JNEUROSCI.1239-10.2010. [pdf]
F Fröhlich and DA McCormick. Endogenous Electric Fields May Guide Neocortical Network Activity. Neuron. 2010 Jul 15;67(1):129-43. doi: 10.1016/j.neuron.2010.06.005. [pdf] Featured in E.O. Mann and O. Paulsen. Local Field Potential Oscillations as a Cortical Soliloquy. Neuron. 2010 July;67(1):3-5. [pdf]
2008
Fröhlich F, Bazhenov M, Iragui-Madoz V, Sejnowski TJ. Potassium Dynamics in the Epileptic Cortex – New Insights on an Old Topic. Neuroscientist. 2008 Oct;14(5):422-33. doi: 10.1177/1073858408317955. Review. [pdf]
Nita DA, Cissé Y, Fröhlich F, Timofeev I. Cortical and thalamic components of neocortical kindling-induced epileptogenesis in behaving cats. Exp Neurol. 2008 Jun;211(2):518-28. doi: 10.1016/j.expneurol.2008.02.028. Epub 2008 Mar 14. [pdf]
Fröhlich F, Bazhenov M, Sejnowski TJ. Pathological effect of homeostatic synaptic scaling on network dynamics in diseases of the cortex. J Neurosci. 2008 Feb 13;28(7):1709-20. doi: 10.1523/JNEUROSCI.4263-07.2008. [pdf] This article has been featured in Nature Neuroscience Reviews [pdf]
Bazhenov M, Timofeev I, Frohlich F, Sejnowski TJ. Cellular and network mechanisms of electrographic seizures. Drug Discov Today Dis Models. 2008;5(1):45-57. [pdf]
2007
F. Fröhlich, I. Timofeev, T.J. Sejnowski and M. Bazhenov. Extracellular potassium dynamics and epileptogenesis. In: Computational Neuroscience in Epilepsy, Editors: Ivan Soltesz and Kevin Staley (2007). [pdf]
2006
Fröhlich F, Bazhenov M. Coexistence of tonic firing and bursting in cortical neurons. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep;74(3 Pt 1):031922. Epub 2006 Sep 28. [pdf]
Fröhlich F, Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ. Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability. J Neurosci. 2006 Jun 7;26(23):6153-62. [pdf]
2005
Fröhlich F, Jezernik S. Feedback control of Hodgkin-Huxley nerve cell dynamics. Control Engineering Practice, 2005 Sept;13(9):Pages 1195-1206 [pdf]
Fröhlich F, Bazhenov M, Timofeev I and Sejnowski TJ. Maintenance and termination of neocortical oscillations by dynamic modulation of intrinsic and synaptic excitability. Thalamus & Related Systems. 2005 June; 3(2): 147-156. [pdf]
2004
Fröhlich F, Jezernik S. Annihilation of single cell neural oscillations by feedforward and feedback control. J Comput Neurosci. 2004 Sep-Oct;17(2):165-78. [pdf]