A Discussion of tACS Literature
NMDA receptor-mediated motor cortex plasticity after 20 Hz transcranial alternating current stimulation.
Wischnewski, M., M. Engelhardt, M.A. Salehinejad, D.J.L.G. Schutter, M.-F. Kuo, & M.A. Nitsche. 2019. NMDA receptor-mediated motor cortex plasticity after 20 Hz transcranial alternating current stimulation. Cerebral Cortex, 29 (7): 2924-31.
Summary: The authors conducted a double-blind, placebo-controlled, crossover design study of the effects of an NMDAR antagonist, dextromethorphan (DMO) on the tACS-induced changes in motor cortex excitability. Single- and paired-pulse (SICI & ICF) TMS was used to measure changes in MEP amplitudes. High-density tACS (4x1 montage, Center: C3; Surround: T7, F3, Cz, P3) was applied to the motor cortex in at 20 Hz. Normalized MEP amplitudes increased after 20 Hz tACS during the course of the placebo visit as expected, but not for the DMO visit, suggesting that NMDARs mediate the aftereffects observed in beta tACS protocols. However, neither placebo nor DMO impacted the excitability profile of ppTMS.
Contributed by: Christopher Walker, PhD
Every week, there are new and exciting scientific papers published on studies that investigated tACS. Reading and understanding these papers unfortunately requires both access to (sometimes quite expensive) scientific journals and in-depth "insider knowledge." Our goal is to share with you brief summaries of tACS studies that give you a big-picture idea of what the publications are about. There are too many studies to feature all of them but we will continuously update this page. If you have a specific study you would like to get featured, please contact us. The contributors are personnel from the Frohlich Lab and the Carolina Center for Neurostimulation.